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KMID : 1007520150240041533
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Food Science and Biotechnology
2015 Volume.24 No. 4 p.1533 ~ p.1540
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β-(1,3)-Glucan Isolated from Agrobacterium Species Induces Maturation of Bone Marrow-derived Dendritic Cells and Drives Th1 Immune Responses
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Byun Eui-Baek
Sung Nak-Yun
Park Sang-Hyun
Park Chul-Hwan
Byun Eui-Hong
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Abstract
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The β-(1,3)-glucan originally isolated from Agrobacterium species was investigated for prompting maturation of dendritic cells (DCs) and driving Th1 immune responses. Bone-marrow derived DCs separated from mice were analyzed for augmentation of cell surface molecule (CD80, CD86, and major histo-compatability complex (MHC) class I/II) expression and pro-inflammatory cytokine production (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6). β-Glucan functionally induced DCs activation via augmentation of CD80, CD86, and MHC class I/II expression and cytokine production (TNF-α, IL-1β, and IL-6). β-Glucan induced secretion of IL-12p70, but not IL-10. Both mitogen-activated protein kinases and nuclear factor (NF)-κB signaling mediated production of pro-inflammatory cytokine induced by β- glucan. β-Glucan-treated DCs exhibited accelerated proliferation of murine splenocytes with increased levels of interferon (IFN)-γ. β-Glucan regulates innate and adaptive immunity via DCs activation and Th1 polarization of immune responses.
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KEYWORD
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β-glucan, agrobacterium, dendritic cell, splenocyte, Th1 immune response
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